The lymphatic system, Brain, and Immunity

Revolutionary new research shows the link between the lymphatic system, the brain, and immunity!

In a stunning discovery that overturns decades of textbook teaching, researchers at the University of Virginia School of Medicine have determined that the brain is directly connected to the immune system by lymphatics that were previously thought not to exist!

The new discovery will open new approaches to diseases such as Multiple Sclerosis and Alzheimer’s Disease.

Jonathan Kipnis, PhD, Professor in the UVA Department of Neuroscience and Director of UVA’s Center for Brain Immunology and Glia (BIG) said, “It changes entirely the way we perceive the neuro-immune interaction.”

He went on to say that they now believe that these newly discovered vessels may play a major role for “every neurological disease that has an immune component to it.”

Kevin Lee, PhD, Chairman of the UVA Department of Neuroscience said that “it will fundamentally change the way people look at the central nervous system’s relationship with the immune system.”

“In Alzheimer’s there are accumulations of big protein chunks in the brain,” Kipnis said. We think they may be accumulating in the brain because they’re not being efficiently removed by these [lymph] vessels.”

The finding was published June 1, 2015 online by the prestigious journal Nature and will appear in a forthcoming print edition. (doi:10.1038/nature14432) The article was authored by Louveau, Smirnov, Timothy J. Keys, Jacob D. Eccles, Sherin J. Rouhani, J. David Peske, Noel C. Derecki, David Castle, James W. Mandell, Lee, Harris, and Kipnis. It was funded by National Institutes of Health grants.

Sources:   Debra Kain – University of Virginia Health System.  The above article was adapted from one which appeared on Neurosciencenews.com

From the ABSTRACT:

http://www.nature.com/nature/journal/vaop/ncurrent/full/nature14432.html.

A groundbreaking discovery sheds new light on neurological diseases such as Multiple Sclerosis and Alzheimer’s Disease that are associated with immune system dysfunction.

The long-held concept of the absence of lymphatic vasculature in the Central Nervous System was smashed last week by a University of Virginia team. The finding was published June 1, 2015 online by the prestigious journal Nature and will appear in a forthcoming print edition. (doi:10.1038/nature14432) The article was authored by Louveau, Smirnov, Timothy J. Keys, Jacob D. Eccles, Sherin J. Rouhani, J. David Peske, Noel C. Derecki, David Castle, James W. Mandell, Lee, Harris, and Kipnis. It was funded by National Institutes of Health grants.

Lyme Disease in Dogs

Did you know your dog can get Lyme Disease? The incidence of this worrisome problem has been rising many areas.  Articles from England, New York, Pennsylvania, and Virginia, just to name a few have been raising the alarm about the tick-borne disease that can have serious consequences for your furry best friend. Over 50% of dog owners are unaware of this fact and the fact that the disease can get to you via your dog ! 

Lyme Disease is caused by Borellelia burgdorferi in the US and is transmitted primarily by deer ticks (Ixodes sp.) rather than the common dog tick.

Dr. Frank Capella of Village Veterinary Hospital in Wampsville New York shares essential information about how to protect your pet in the first link below. 

http://wibx950.com/ticks-and-lyme-disease-how-to-protect-your-pet/

The next links give additional information about the increase in canine Lyme Disease and why it is such a problem.

http://www.dailymail.co.uk/health/article-3050954/Dog-owners-unaware-pets-transmit-Lyme-disease-say-vets.html

http://www.mckeancountyanimalhospital.com/lyme-disease-on-the-rise/

Although the last link (below) begins with a discussion of the increase in Virginia, it has the best information in general about the Lyme Disease in dogs.

http://augustafreepress.com/lyme-disease-on-the-rise-among-people-dogs-in-virginias-new-river-valley/

Danger in Topical Teething Pain Relievers

Oral viscous lidocaine 2% solutions or benzocaine solutions should not be used to treat infants and children with teething pain because of serious health risks.  The US Food and Drug Administration (FDA) said, “Use in infants and young children can cause serious harm, including death.”

“Topical pain relievers and medications that are rubbed on the gums are not necessary or even useful because they wash out of the baby’s mouth within minutes. When too much viscous lidocaine is given to infants and young children or they accidentally swallow too much, it can result in seizures, severe brain injury, and problems with the heart,” the FDA warns.

In 2011, the FDA warned that  using OTC benzocaine gels or liquids for teething or mouth pain can cause a rare but serious condition called methemoglobinemia.  It is life-threatening and can result in death.  Benzocaine containing medications are sold under names such as Anbesol, Hurricaine, Orajel, Baby Orajel, Orabase.

The FDA advises parents and caregivers to follow the American Academy of Pediatrics’ recommendations for treating teething pain: use a teething ring chilled in the refrigerator (not frozen) or gently rub or massage the child’s gums with your finger to relieve the symptoms.

Edited from the article: Oral Lidocaine for Teething Pain May Cause Harm, FDA Says. Medscape. Jun 26, 2014.